Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Ken Inoki, Yong Li, Tianquan Zhu et al. · Nature Cell Biology · 2002 · 3.1K citations

Life Sciences, Cell Biology, Molecular Biology +6

Identification and characterization of the tuberous sclerosis gene on chromosome 16

Cell · 1993 · 1.7K citations

Life Sciences, Genetics, Molecular Genetics +7

Identification of the Tuberous Sclerosis Gene <i>TSC1</i> on Chromosome 9q34

Marjon van Slegtenhorst, Ronald De Hoogt, Caroline Hermans et al. · Science · 1997 · 1.7K citations

Medicine, Genetics, Molecular Genetics +16

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

Andrew R. Tee, Diane C. Fingar, Brendan D. Manning et al. · Proceedings of the National Academy of Sciences · 2002 · 828 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling

Xinsheng Gao, Yong Zhang, Peter Arrazola et al. · Nature Cell Biology · 2002 · 670 citations

Life Sciences, Molecular Biology, Oncology +12