Concepedia

Synthesis of a novel series of 2,3,4-trisubstituted oxazolidines designed by isosteric replacement or rigidification of the structure and cytotoxic evaluation

Saulo Fernandes de Andrade, Cláudia Salviano Teixeira, Jonas Pereira Ramos, Marcela Silva Lopes, Rodrigo Maia de Pádua, Mônica Cristina Oliveira, Elaine M. Souza‐Fagundes, Ricardo José Alves

MedChemComm · 2014 · 16 citations · 22 references

DOI

Concepts

Abstract

Rigidification of the structure of 2,3,4-trisubstituted oxazolidines enhances the activity against LNCaP cells without affecting normal cell proliferation.

References

22

Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide

Hideki Mizutani, Saeko Tada‐Oikawa, Yusuke Hiraku et al. · Life Sciences · 2005 · 468 citations

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Synthesis and biological evaluation of γ-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists

Frank W. Foss, Ashley H. Snyder, Michael D. Davis et al. · Bioorganic & Medicinal Chemistry · 2006 · 158 citations · Full text

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Mechanisms of Cisplatin-Induced Apoptosis and of Cisplatin Sensitivity: Potential of BIN1 to Act as a Potent Predictor of Cisplatin Sensitivity in Gastric Cancer Treatment

Satoshi Tanida, Tsutomu Mizoshita, Keiji Ozeki et al. · International Journal of Surgical Oncology · 2012 · 126 citations · Full text

, , +17

4-Phenylpyrrolo[3,4-<i>c</i>]carbazole-1,3(2<i>H</i>,6<i>H</i>)-dione Inhibitors of the Checkpoint Kinase Wee1. Structure−Activity Relationships for Chromophore Modification and Phenyl Ring Substitution

Brian D. Palmer, Andrew M. Thompson, R J Booth et al. · Journal of Medicinal Chemistry · 2006 · 110 citations · Full text

, , +15

1,1,-DIMETHYLETHYL (S)- OR (R)-4-FORMYL-2,2-DIMETHYL-3-OXAZOLIDINECARBOXYLATE: A USEFUL SERINAL DERIVATIVE

Organic Syntheses · 1992 · 89 citations

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