Concepedia

Isosteric Substitution

Isosteric Substitution is a bioisosteric strategy in medicinal chemistry that involves the replacement of a functional group or atom within a molecule with another of similar size, shape, and electronic properties to preserve or enhance pharmacokinetic and pharmacodynamic profiles while maintaining structural similarity.

156

Publications

7.1K

Citations

1K

Authors

243

Institutions

Publications per year

2017–2026

27

Parents

Publications

156

Pyrethrum flowers and pyrethroid insecticides.

John E. Casida · Environmental Health Perspectives · 1980 · 334 citations · Full text

, , +16

Nature of Amide Carbonyl−Carbonyl Interactions in Proteins

Amit Choudhary, Deepa Gandla, Grant R. Krow et al. · Journal of the American Chemical Society · 2009 · 284 citations · Full text

, , +17

Structure Property Relationships of Carboxylic Acid Isosteres

Pierrik Lassalas, Bryant Gay, Caroline Lasfargeas et al. · Journal of Medicinal Chemistry · 2016 · 284 citations · Full text

, , +17

Two-Dimensional Organic–Inorganic Perovskite Ferroelectric Semiconductors with Fluorinated Aromatic Spacers

Ping‐Ping Shi, Siqi Lu, Xian‐Jiang Song et al. · Journal of the American Chemical Society · 2019 · 235 citations

, , +17

Synthesis and Evaluation of 1,2,3-Triazole Containing Analogues of the Immunostimulant α-GalCer

Tae‐Ho Lee, Minjae Cho, Sung‐Youl Ko et al. · Journal of Medicinal Chemistry · 2007 · 180 citations

, , +15

1–5 of 156

Authors

1K

  1. AB
    Amos B. Smith

    University of Pennsylvania, United States

    2 publications · 338 citations

    2

    h-index

  2. MJ
    Michael J. James

    University of York, United Kingdom

    2 publications · 338 citations

    2

    h-index

  3. MC
    Miriam Corredor

    Institute of Advanced Chemistry of Catalonia, Spain

    2 publications · 35 citations

    2

    h-index

  4. NB
    Nediljko Budiša

    Technische Universität Berlin, Germany

    2 publications · 190 citations

    2

    h-index

  5. MO
    Mar Orzáez

    Centro de Investigacion Principe Felipe, Spain

    2 publications · 35 citations

    2

    h-index

1–5 of 1K

Institutions

243

  1. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    20 publications

    1.2K citations

  2. Inserm

    Paris, France

    4 h-index

    24 publications

    1K citations

  3. University of Wisconsin–Madison

    Madison, United States

    4 h-index

    13 publications

    1.8K citations

  4. Université Paris Cité

    Paris, France

    3 h-index

    11 publications

    509 citations

  5. University of Nottingham

    Nottingham, United Kingdom

    3 h-index

    12 publications

    757 citations

  6. University of California San Diego

    San Diego, United States

    3 h-index

    6 publications

    241 citations

  7. National Institutes of Health

    Bethesda, United States

    3 h-index

    7 publications

    426 citations

  8. University of California, San Francisco

    San Francisco, United States

    3 h-index

    8 publications

    276 citations

1–8 of 243

Venues

  1. Journal of Medicinal Chemistry

    33 publications · 2K citations

    25

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    11 publications · 240 citations

    10

    h-index

  3. Journal of the American Chemical Society

    JACS · 7 publications · 975 citations

    7

    h-index

  4. European Journal of Medicinal Chemistry

    5 publications · 219 citations

    5

    h-index

  5. Tetrahedron Letters

    4 publications · 124 citations

    4

    h-index

1–5