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Peptide Chain Termination, Codon, Protein Factor, and Ribosomal Requirements
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1969
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GeneticsMolecular BiologyPeptide ScienceMolecular GeneticsPeptide Chain TerminationGenomicsProtein SynthesisTerminator CodonProtein FoldingGene StructureProteomicsGenetic StudiesGene ExpressionProtein BiosynthesisNatural SciencesGenetic MechanismPeptide SynthesisMedicinePeptide Chain
Results of biochemical studies (Last et al., 1967; Capecchi, 1967; Bretscher, 1968) and genetic studies (Weigert and Garen, 1965; Brenner, Stretton, and Kaplan, 1965) show that the synthesis of a peptide chain is terminated upon translation of messenger RNA codons UAA or UAG. Genetic evidence also indicates UGA functions as a barrier or terminator codon (Brenner, Barnett, Katz, and Crick, 1967; Weigert, Lanka, and Garen, 1967).