Cold Spring Harbor Symposia on Quantitative Biology · 1969 · 83 citations · 0 references
Life SciencesBiochemistryGeneticsBiochemical GeneticsNucleic Acid BiochemistryProtein TranslationCodon RecognitionProtein SynthesisRibosome FunctionTranslation In EukaryotesTranslation TerminationTranslational RegulationChain TerminationMrna Translation TerminationPeptide Chain ElongationPremature Termination CodonsPremature Translation TerminationTranslation Termination AnalysisTranslation Termination FactorsTranslation Termination Regulation
Results of biochemical studies (Last et al., 1967; Capecchi, 1967; Bretscher, 1968) and genetic studies (Weigert and Garen, 1965; Brenner, Stretton, and Kaplan, 1965) show that the synthesis of a peptide chain is terminated upon translation of messenger RNA codons UAA or UAG. Genetic evidence also indicates UGA functions as a barrier or terminator codon (Brenner, Barnett, Katz, and Crick, 1967; Weigert, Lanka, and Garen, 1967).