J L Goldstein

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

Hitoshi Shimano, Jay D. Horton, Iichiro Shimomura et al. · Journal of Clinical Investigation · 1997 · 831 citations · Full text

Fatty Liver Disease, Transgenic Mice, Transcriptional Regulation +19

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

Hitoshi Shimano, Jay D. Horton, Robert E. Hammer et al. · Journal of Clinical Investigation · 1996 · 815 citations · Full text

Fatty Liver Disease, Transgenic Mice, Cellular Physiology +22

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

Jay D. Horton, Iichiro Shimomura, Matthew Brown et al. · Journal of Clinical Investigation · 1998 · 704 citations · Full text

Metabolic Syndrome, Cholesterol Biosynthesis, Biochemistry +15

Increased binding of low density lipoprotein to liver membranes from rats treated with 17 alpha-ethinyl estradiol.

Petri T. Kovanen, M S Brown, J L Goldstein · Journal of Biological Chemistry · 1979 · 568 citations · Full text

Oxysterol, Hepatology, Biochemistry +11

Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

David W. Bilheimer, Scott M. Grundy, Matthew S. Brown et al. · Proceedings of the National Academy of Sciences · 1983 · 559 citations · Full text

Hyperlipidemia, Mevinolin Treatment, Molecular Pharmacology +17