Increase in postprandial serum insulin levels in epileptic patients with valproic acid therapy

Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge

William T. Friedewald, Robert I. Levy, Donald S. Fredrickson · Clinical Chemistry · 1972 · 32.5K citations

Life Sciences, Biochemistry, Clinical Biochemistry +14

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

David R. Matthews, J P Hosker, A. Rudenski et al. · Diabetologia · 1985 · 31.4K citations · Full text

Medicine, Endocrinology, Physiology +17

Positional cloning of the mouse obese gene and its human homologue

Yiying Zhang, Ricardo Proenca, Margherita Maffei et al. · Nature · 1994 · 13.4K citations

Life Sciences, Genetics, Molecular Genetics +12

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Gökhan S. Hotamışlıgil, Narinder S. Shargill, Bruce M. Spiegelman · Science · 1993 · 7.5K citations

Medicine, Endocrinology, Molecular Biology +17

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

Robert V. Considine, Madhur K. Sinha, Mark L. Heiman et al. · New England Journal of Medicine · 1996 · 6.3K citations

Medicine, Endocrinology, Nutritional Sciences +7