Discovery of furan-2-carbohydrazides as orally active glucagon receptor antagonists

Expression cloning and signaling properties of the rat glucagon receptor

L. Jelinek, Si Lok, G Rosenberg et al. · Science · 1993 · 400 citations

Life Sciences, Endocrinology, Physiology +17

Documentation of Hyperglucagonemia Throughout the Day in Nonobese and Obese Patients with Noninsulin-Dependent Diabetes Mellitus*

Gerald M. Reaven, Y.-D. I. CHEN, A. Golay et al. · The Journal of Clinical Endocrinology & Metabolism · 1987 · 329 citations

Medicine, Endocrinology, Physiology +9

Role of Hyperglucagonemia in Maintenance of Increased Rates of Hepatic Glucose Output in Type II Diabetics

Linda Schaeffer, Paul Shragg, Orville Kolterman · Diabetes · 1987 · 300 citations

Medicine, Endocrinology, Internal Medicine +16

Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans

Kitt Falk Petersen, John T. Sullivan · Diabetologia · 2001 · 208 citations · Full text

Life Sciences, Endocrinology, Physiology +16

Optimization of Alkylidene Hydrazide Based Human Glucagon Receptor Antagonists. Discovery of the Highly Potent and Orally Available 3-Cyano-4-hydroxybenzoic Acid [1-(2,3,5,6-Tetramethylbenzyl)-1<i>H</i>-indol-4-ylmethylene]hydrazide

Peter Madsen, Anthony Ling, Michael Plewe et al. · Journal of Medicinal Chemistry · 2002 · 87 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17