Toshiyuki Negoro

Novel, Highly Potent Aldose Reductase Inhibitors:  (<i>R</i>)-(−)-2-(4-Bromo-2-fluorobenzyl)-1,2,3,4-tetrahydropyrrolo[1,2-<i>a</i>]pyrazine- 4-spiro-3‘-pyrrolidine-1,2‘,3,5‘-tetrone (AS-3201) and Its Congeners

Toshiyuki Negoro, Makoto Murata, S. UEDA et al. · Journal of Medicinal Chemistry · 1998 · 123 citations · Full text

Pharmaceutical Science, Bioorganic Chemistry, Aldo-keto Reductase +17

Discovery of furan-2-carbohydrazides as orally active glucagon receptor antagonists

Futoshi Hasegawa, Kazumi Niidome, Chiaki Migihashi et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 66 citations · Full text

Medicinal Chemistry, Biochemistry, G Protein-coupled Receptor +7

Stereospecific recognition of a spirosuccinimide type aldose reductase inhibitor (AS-3201) by plasma proteins: A significant role of specific binding by serum albumin in the improved potency and stability

Masuo Kurono, Akihito Fujii, Makoto Murata et al. · Biochemical Pharmacology · 2005 · 41 citations

Aldo-keto Reductase, Serum Albumin, Biochemistry +9

Synthesis and structure-activity relationships of 1-substituted 4-(1,2-diphenylethyl)piperazine derivatives having narcotic agonist and antagonist activity

Kagayaki Natsuka, Hideo Nakamura, Yoshinori Nishikawa et al. · Journal of Medicinal Chemistry · 1987 · 34 citations

Medicinal Chemistry, Pharmaceutical Chemistry, Derivative (Chemistry) +15

Studies on 1-substituted 4-(1,2-diphenylethyl)piperazine derivatives and their analgesic activities. 2. Structure-activity relationships of 1-cycloalkyl-4-(1,2-diphenylethyl)piperazines

Kagayaki Natsuka, Hideo Nakamura, Toshiyuki Negoro et al. · Journal of Medicinal Chemistry · 1978 · 21 citations