Higher activity of peripheral blood angiotensin-converting enzyme is associated with later-onset of Alzheimer's disease

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Life Sciences, Neurobiology, Neuroscience +14

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.

Brigitte Rigat, C. Hübert, F Alhenc‐Gelas et al. · Journal of Clinical Investigation · 1990 · 3.8K citations · Full text

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Clinical and Pathological Diagnosis of Frontotemporal Dementia

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Medicine, Neurology, Psychiatry +12

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

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Life Sciences, Molecular Biology, Neuroscience +17

Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain <i>in vivo</i>

Wesley Farris, Stefan Mansourian, Yang Chang et al. · Proceedings of the National Academy of Sciences · 2003 · 1.5K citations · Full text

Life Sciences, Genetics, Neuroscience +15