Concepedia

Antisense oligonucleotides: Efficient synthesis of 2′-O-methoxyethyl phosphorothioate oligonucleotides using 4,5-dicyanoimidazole. Are these oligonucleotides comparable to those synthesized using 1H-tetrazole as coupling activator?

Zhiwei Wang, Andy Siwkowski, Walt F. Lima, Phil Olsen, Vasulinga T. Ravikumar

Bioorganic & Medicinal Chemistry · 2006 · 13 citations · 22 references

DOI

Concepts

References

22

Kinetic characteristics of <i>Escherichia coli</i> RNase H1: cleavage of various antisense oligonucleotide-RNA duplexes

Stanley T. Crooke, Kristina M. Lemonidis, Lorna Neilson et al. · Biochemical Journal · 1995 · 188 citations · Full text

, , +14

Second Generation of Antisense Oligonucleotides: From Nuclease Resistance to Biological Efficacy in Animals

Karl‐Heinz Altmann, Nicholas M. Dean, Doriano Fabbro et al. · CHIMIA International Journal for Chemistry · 1996 · 173 citations · Full text

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Efficient activation of nucleoside phosphoramidites with 4,5- dicyanoimidazole during oligonucleotide synthesis

Chandra Vargeese · Nucleic Acids Research · 1998 · 132 citations · Full text

, , +13

Binding Affinity and Specificity of <i>Escherichia coli</i> RNase H1:  Impact on the Kinetics of Catalysis of Antisense Oligonucleotide−RNA Hybrids

Walt F. Lima, Stanley T. Crooke · Biochemistry · 1997 · 117 citations

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Synthesis of High-Quality Antisense Drugs. Addition of Acrylonitrile to Phosphorothioate Oligonucleotides:  Adduct Characterization and Avoidance

Daniel C. Capaldi, Hans Gaus, Achim H. Krotz et al. · Organic Process Research & Development · 2003 · 81 citations

, , +17