Daniel C. Capaldi

Impurities in Oligonucleotide Drug Substances and Drug Products

Daniel C. Capaldi, Andy Teasdale, Scott P. Henry et al. · Nucleic Acid Therapeutics · 2017 · 125 citations

White Paper, Molecular Biology, Nucleic Acid Chemistry +17

Synthesis of High-Quality Antisense Drugs. Addition of Acrylonitrile to Phosphorothioate Oligonucleotides:  Adduct Characterization and Avoidance

Daniel C. Capaldi, Hans Gaus, Achim H. Krotz et al. · Organic Process Research & Development · 2003 · 79 citations

Bioorganic Chemistry, Dna, Oligonucleotide Manufacture +20

Synthesis of Antisense Oligonucleotides:  Replacement of 3H-1,2-Benzodithiol-3-one 1,1-Dioxide (Beaucage Reagent) with Phenylacetyl Disulfide (PADS) As Efficient Sulfurization Reagent:  From Bench to Bulk Manufacture of Active Pharmaceutical Ingredient

Zacharia S. Cheruvallath, Recaldo L. Carty, Max N. Moore et al. · Organic Process Research & Development · 1999 · 53 citations

Pharmaceutical Science, Bioorganic Chemistry, Engineering +19

Use of the 1-(2-fluorophenyl)-4-methoxypiperidin-4-yl (Fpmp) and related protecting groups in oligoribonucleotide synthesis: stability of internucleotide linkages to aqueous acid

Daniel C. Capaldi, Colin B. Reese · Nucleic Acids Research · 1994 · 53 citations · Full text

Assay, Purity, and Impurity Profile of Phosphorothioate Oligonucleotide Therapeutics by Ion Pair–HPLC–MS

Claus Rentel, Hans Gaus, Kym Bradley et al. · Nucleic Acid Therapeutics · 2022 · 49 citations

Engineering, Phosphorothioate Oligonucleotide Therapeutics, Medicinal Chemistry +23