CCL20 produced in the cytokine network of rheumatoid arthritis recruits CCR6+ mononuclear cells and enhances the production of IL-6

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Heon Park, Zhaoxia Li, Xuexian O. Yang et al. · Nature Immunology · 2005 · 4.2K citations · Full text

Life Sciences, Cell Biology, Immunology +17

Transforming growth factor-β induces development of the TH17 lineage

Paul R. Mangan, Laurie E. Harrington, Darrell B. O’Quinn et al. · Nature · 2006 · 3K citations

Life Sciences, Immunology, Molecular Biology +11

Development, cytokine profile and function of human interleukin 17–producing helper T cells

Nicholas J. Wilson, Katia Boniface, Jason R. Chan et al. · Nature Immunology · 2007 · 2K citations

Life Sciences, Cell Biology, Immunology +14

Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

Eva V. Acosta Rodríguez, Giorgio Napolitani, Antonio Lanzavecchia et al. · Nature Immunology · 2007 · 1.8K citations

Life Sciences, Cell Biology, Immunology +16

Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model

Keiji Hirota, Hiroyuki Yoshitomi, Motomu Hashimoto et al. · The Journal of Experimental Medicine · 2007 · 924 citations · Full text

Medicine, Immunology, Pathology +13