Concepedia

Metformin inhibits heme oxygenase-1 expression in cancer cells through inactivation of Raf-ERK-Nrf2 signaling and AMPK-independent pathways

Minh Truong, Hyung Gyun Kim, Tilak Khanal, Jae Ho Choi, Dong Hee Kim, Tae Cheon Jeong, Hye Gwang Jeong

Toxicology and Applied Pharmacology · 2013 · 128 citations · 40 references

DOI

Concepts

References

40

Metformin and reduced risk of cancer in diabetic patients

Josie Evans, Louise A. Donnelly, Alistair Emslie‐Smith et al. · BMJ · 2005 · 2.4K citations · Full text

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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

Gina M. DeNicola, Florian A. Karreth, Timothy J. Humpton et al. · Nature · 2011 · 2.2K citations · Full text

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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Reuben J. Shaw, Katja Lamia, Debbie S. Vasquez et al. · Science · 2005 · 1.9K citations

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Metformin Is an AMP Kinase–Dependent Growth Inhibitor for Breast Cancer Cells

Mahvash Zakikhani, Ryan J.O. Dowling, I. George Fantus et al. · Cancer Research · 2006 · 1K citations · Full text

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Increased Cancer-Related Mortality for Patients With Type 2 Diabetes Who Use Sulfonylureas or Insulin

Samantha L. Bowker, Sumit R. Majumdar, Paul J. Veugelers et al. · Diabetes Care · 2006 · 930 citations · Full text

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