Oxidative Medicine and Cellular Longevity · 2014 · 88 citations · 16 references
MedicineOncologyPharmacologyApoptosisCancer PharmacologyChemotherapyApoptosis In CancerApoptosis PharmacologyCytotoxic ChemotherapyOvarian CancerOvarian Cancer PharmacotherapyReactive Oxygen SpeciesAnticancer ActivityAnticancer ChemotherapyCancer Cell ApoptosisCancer Cell Proliferation InhibitionM Phase ArrestOvarian Cancer ChemotherapyOvarian Cancer TreatmentOxidative Stress In Cancer
Piperlongumine (PL), a natural alkaloid from Piper longum L., possesses the highly selective and effective anticancer property. However, the effect of PL on ovarian cancer cells is still unknown. In this study, we firstly demonstrate that PL selectively inhibited cell growth of human ovarian cancer cells. Furthermore, PL notably induced cell apoptosis, G2/M phase arrest, and accumulation of the intracellular reactive oxidative species (ROS) in a dose- and time-dependent manner. Pretreatment with antioxidant N-acety-L-cysteine could totally reverse the PL-induced ROS accumulation and cell apoptosis. In addition, low dose of PL/cisplatin or paclitaxel combination therapies had a synergistic antigrowth effect on human ovarian cancer cells. Collectively, our study provides new therapeutic potential of PL on human ovarian cancer.
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Production of large amounts of hydrogen peroxide by human tumor cells.
Ted P. Szatrowski, Carl Nathan · PubMed · 1991 · 2.5K citations
Selective killing of cancer cells by a small molecule targeting the stress response to ROS
Lakshmi Raj, Takao Ide, Aditi U. Gurkar et al. · Nature · 2011 · 1K citations
Medicine, Cancer Biology, Oncology +15