Concepedia

The Synthesis and Antiviral Activity of 4-Fluoro-1-β-D-ribofuranosyl-1H-pyrazole-3-carboxamide

Richard Storer, C. ASHTON, Anthony D. Baxter, Michael M. Hann, Clara L.P. Marr, Andrew M. Mason, Chi-Leung Mo, Peter L. Myers, Stewart A. Noble, Charles R. Penn,

Nucleosides and Nucleotides · 1999 · 82 citations · 15 references

DOI

Concepts

Abstract

A novel fluoropyrazole ribonucleoside has been shown to have significant anti-influenza activity in vitro. The compound is compared and contrasted with the structurally-related compound ribavirin in attempts to identify factors having significant bearing on the mode of action of both compounds.

References

15

Mechanism of Action of 1-β-D-Ribofuranosyl-1,2,4-Triazole-3-Carboxamide (Virazole), A New Broad-Spectrum Antiviral Agent

David Streeter, J. T. WITKOWSKI, G. P. Khare et al. · Proceedings of the National Academy of Sciences · 1973 · 480 citations · Full text

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Design, synthesis, and broad spectrum antiviral activity of 1-.beta.-D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides

J. T. WITKOWSKI, Roland K. Robins, Robert W. Sidwell et al. · Journal of Medicinal Chemistry · 1972 · 467 citations

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Inhibition of Influenza Virus Ribonucleic Acid Polymerase by Ribavirin Triphosphate

B. Eriksson, Erik Helgstrand, Nils Gunnar Johansson et al. · Antimicrobial Agents and Chemotherapy · 1977 · 257 citations · Full text

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The broad spectrum antiviral agent ribavirin inhibits capping of mRNA

Biswendu B. Goswami, Ernest Borek, Opendra K. Sharma et al. · Biochemical and Biophysical Research Communications · 1979 · 207 citations

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Pyrazole-related nucleosides. Synthesis and antiviral/antitumor activity of some substituted pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosides

Stefano Manfredini, Rita Bazzanini, Pier Giovanni Baraldi et al. · Journal of Medicinal Chemistry · 1992 · 115 citations

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