Concepedia

Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling

John W. Scott, Naomi X.Y. Ling, Samah M. A. Issa, Toby A. Dite, Matthew T. O’Brien, Zhiping Chen, Sandra Galić, Christopher G. Langendorf, Gregory R. Steinberg, Bruce E. Kemp,

Chemistry & Biology · 2014 · 155 citations · 33 references

DOI

Concepts

References

33

LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade

Angela Woods, Stephen R. Johnstone, Kristina Dickerson et al. · Current Biology · 2003 · 1.6K citations

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Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

Philip D. Jeffrey, Alicia A. Russo, Kornélia Polyák et al. · Nature · 1995 · 1.4K citations

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Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

Marc Foretz, Sophie Hébrard, Jocelyne Leclerc et al. · Journal of Clinical Investigation · 2010 · 1.2K citations · Full text

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Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

Barbara L. Cool, Bradley A. Zinker, William J. Chiou et al. · Cell Metabolism · 2006 · 918 citations · Full text

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Structure of mammalian AMPK and its regulation by ADP

Bing Xiao, Matthew J. Sanders, E. Underwood et al. · Nature · 2011 · 917 citations · Full text

, , +9