Unveiling the Post-PKS Redox Tailoring Steps in Biosynthesis of the Type II Polyketide Antitumor Antibiotic Xantholipin

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Julie Thompson, Desmond G. Higgins, Toby J. Gibson · Nucleic Acids Research · 1994 · 64.9K citations · Full text

Life Sciences, Bioinformatics, Sequence Analysis +14

MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment

Sudhir Kumar · Briefings in Bioinformatics · 2004 · 11.8K citations · Full text

Life Sciences, Bioinformatics, Evolutionary Biology +16

PCR-targeted <i>Streptomyces</i> gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin

Bertolt Gust, Gregory L. Challis, Kay Fowler et al. · Proceedings of the National Academy of Sciences · 2003 · 1.4K citations

Life Sciences, Biotechnology, Microbiology +14

Engineered Biosynthesis of Novel Polyketides

Robert McDaniel, Susanne Ebert‐Khosla, David A. Hopwood et al. · Science · 1993 · 470 citations

Engineering, Biochemistry, Biotechnology +16

Evidence that the Extracytoplasmic Function Sigma Factor ς ^E Is Required for Normal Cell Wall Structure in <i>Streptomyces coelicolor</i> A3(2)

Mark S. B. Paget, Leony Chamberlin, Abdelmadjid Atrih et al. · Journal of Bacteriology · 1999 · 415 citations · Full text

Life Sciences, Microbiology, Molecular Biology +13