Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

Suzanne L. Mansour, Kirk R. Thomas, Mario R. Capecchi · Nature · 1988 · 1.7K citations

Knockout Mouse, Embryonic Stem Cell, Lineage Plasticity +12

Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development

Michael A. Rudnicki, Thomas Braun, Shuji Hinuma et al. · Cell · 1992 · 988 citations

Knockout Mouse, Muscle Physiology, Muscle Function +11

Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis.

Kensuke Miyake, Irving L. Weissman, Joel S. Greenberger et al. · The Journal of Experimental Medicine · 1991 · 615 citations · Full text

Lymphocyte Development, Cell Adhesion, Immunology +16

Production of homozygous mutant ES cells with a single targeting construct.

Richard M. Mortensen, David A. Conner, Stephen Chao et al. · Molecular and Cellular Biology · 1992 · 413 citations · Full text

Genetics, Embryonic Stem, Cell Culture +16

Modulation of gene expression by calreticulin binding to the glucocorticoid receptor

Kimberly Burns, Brenda Duggan, Eric A. Atkinson et al. · Nature · 1994 · 389 citations

Calreticulin Binding, Signal Transduction, G Protein-coupled Receptor +12