Concepedia

Integrin-mediated Interactions

Integrin-Mediated Interactions is a molecular mechanism in cell-scaffold interactions wherein integrin receptors on the cell surface bind specifically to ligands on the scaffold matrix, thereby enabling focal adhesion formation, intracellular signaling, and mechanotransduction that regulate cellular attachment, migration, and differentiation.

2.4K

Publications

199K

Citations

11.7K

Authors

2.1K

Institutions

Publications per year

2017–2026

345

Parents

Publications

2.4K

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

John S. Munger, Xiaozhu Huang, Hisaaki Kawakatsu et al. · Cell · 1999 · 2.1K citations

, , +16

Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness

Sean P. Palecek, Joseph C. Loftus, Mark H. Ginsberg et al. · Nature · 1997 · 1.4K citations

, , +16

Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN

Masahito Tamura, Jianguo Gu, Kazue Matsumoto et al. · Science · 1998 · 1.2K citations

, , +17

Functional atlas of the integrin adhesome

Ronen Zaidel‐Bar, Shalev Itzkovitz, Avi Ma’ayan et al. · Nature Cell Biology · 2007 · 1.2K citations

, , +14

Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression

Philip H. Jones, Fiona M. Watt · Cell · 1993 · 1.1K citations

, , +14

1–5 of 2.4K

Authors

11.7K

  1. MJ
    Martin J. Humphries

    University of Manchester, United Kingdom

    33 publications · 3.6K citations

    27

    h-index

  2. TA
    Timothy A. Springer

    Harvard University, United States

    28 publications · 4.3K citations

    25

    h-index

  3. RF
    Reinhard Fässler

    Max Planck Institute of Biochemistry, Germany

    24 publications · 3.2K citations

    24

    h-index

  4. DS
    Dean Sheppard

    University of California, San Francisco, United States

    25 publications · 6K citations

    21

    h-index

  5. YT
    Yoshikazu Takada

    Scripps Research Institute, United States

    26 publications · 2K citations

    20

    h-index

1–5 of 11.7K

Institutions

2.1K

  1. Harvard University

    Cambridge, United States

    68 h-index

    463 publications

    65.1K citations

  2. University of California, San Francisco

    San Francisco, United States

    54 h-index

    317 publications

    67.1K citations

  3. Scripps Research Institute

    San Diego, United States

    43 h-index

    191 publications

    23.3K citations

  4. Dana-Farber Cancer Institute

    Boston, United States

    40 h-index

    176 publications

    28.2K citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    39 h-index

    124 publications

    26.4K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    37 h-index

    253 publications

    14.7K citations

  7. University of Manchester

    Manchester, United Kingdom

    34 h-index

    129 publications

    15.8K citations

  8. The University of Osaka

    Osaka, Japan

    32 h-index

    240 publications

    22.9K citations

1–8 of 2.1K

Venues

  1. Journal of Biological Chemistry

    JBC · 261 publications · 23.9K citations

    93

    h-index

  2. The Journal of Cell Biology

    JCB · 57 publications · 10.4K citations

    51

    h-index

  3. Blood

    72 publications · 7.2K citations

    49

    h-index

  4. Experimental Cell Research

    ECR · 76 publications · 5K citations

    43

    h-index

  5. Journal of Cell Science

    57 publications · 5.3K citations

    39

    h-index

1–5