Elevated interleukin-18 levels correlated with disease activity in systemic lupus erythematosus

Cloning of a new cytokine that induces IFN-γ production by T cells

Haruki Okamura, Hiroko Tsutsui, Toshinori Komatsu et al. · Nature · 1995 · 2.6K citations

Life Sciences, Biotechnology, Immunology +16

IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production.

Tomohiro Yoshimoto, Kiyoshi Takeda, Takashi Tanaka et al. · PubMed · 1998 · 774 citations

Life Sciences, Cell Biology, Immunology +17

A proinflammatory role for IL-18 in rheumatoid arthritis

J. Alastair Gracie, Rosalyn Forsey, Woon Ling Chan et al. · Journal of Clinical Investigation · 1999 · 643 citations · Full text

Medicine, Immunology, Pathobiology +17

Differential Cytokine and Chemokine Gene Expression by Human NK Cells Following Activation with IL-18 or IL-15 in Combination with IL-12: Implications for the Innate Immune Response

Todd A. Fehniger, Manisha H. Shah, Matthew J. Turner et al. · The Journal of Immunology · 1999 · 640 citations · Full text

Life Sciences, Cell Biology, Immunology +16

IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12

Keizo Kohno, Jiro Kataoka, Takashi Ohtsuki et al. · The Journal of Immunology · 1997 · 520 citations

Life Sciences, Cell Biology, Immunology +16