Combination of necroptosis and apoptosis inhibition enhances cardioprotection against myocardial ischemia–reperfusion injury

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

Alexei Degterev, Zhihong Huang, Michael Boyce et al. · Nature Chemical Biology · 2005 · 3K citations

Medicine, Medicinal Chemistry, Pharmacology +17

Identification of RIP1 kinase as a specific cellular target of necrostatins

Alexei Degterev, Junichi Hitomi, Megan Germscheid et al. · Nature Chemical Biology · 2008 · 2K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

Nils Holler, Rossana Zaru, Olivier Micheau et al. · Nature Immunology · 2000 · 1.9K citations

Life Sciences, Cell Biology, Molecular Biology +14

Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats.

Jan Kajstura, Wei Cheng, Krzysztof Reiss et al. · PubMed · 1996 · 1K citations

Life Sciences, Pathobiology, Physiology +11

Early phase acute myocardial infarct size quantification: Validation of the triphenyl tetrazolium chloride tissue enzyme staining technique

Michael C. Fishbein, Samuel Meerbaum, Jacob Rit et al. · American Heart Journal · 1981 · 927 citations

Medicine, Biochemistry, Cardiology +9