Consensus models for CDK5 inhibitors in silico and their application to inhibitor discovery

Directory of Useful Decoys, Enhanced (DUD-E): Better Ligands and Decoys for Better Benchmarking

Michael M. Mysinger, Michael Carchia, John J. Irwin et al. · Journal of Medicinal Chemistry · 2012 · 2.4K citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +17

BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities

Tianbo Liu, Yu‐Ting Lin, X. Wen et al. · Nucleic Acids Research · 2006 · 2.1K citations · Full text

Life Sciences, Bioinformatics, Medicinal Chemistry +17

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

Gentry N. Patrick, Lawrence Zukerberg, Margareta Nikolić et al. · Nature · 1999 · 1.5K citations

Life Sciences, Molecular Genetics, Neuroscience +10

Aberrant Cdk5 Activation by p25 Triggers Pathological Events Leading to Neurodegeneration and Neurofibrillary Tangles

Jonathan C. Cruz, Huang-Chun Tseng, Joseph Goldman et al. · Neuron · 2003 · 613 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +12

Classification of Kinase Inhibitors Using a Bayesian Model

Xiaoyang Xia, Edward Maliski, Paul Gallant et al. · Journal of Medicinal Chemistry · 2004 · 359 citations

Pharmacy, Bioinformatics, Medicinal Chemistry +13