Optimising inhibitors of Trypanothione reductase using solid-phase chemistry

Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages

Carole Dumas · The EMBO Journal · 1997 · 302 citations · Full text

Reductive Stress, Biochemistry, Parasitic Protozoa +13

Disulfide‐Reductase Inhibitors as Chemotherapeutic Agents: The Design of Drugs for Trypanosomiasis and Malaria

R. Heiner Schirmer, Joachim G. Müller, R. Luise Krauth‐Siegel · Angewandte Chemie International Edition in English · 1995 · 214 citations

Antiparasitic Agent, Malaria, Pharmacotherapy +20

Active site of trypanothione reductase

William N. Hunter, Susan Bailey, J. Habash et al. · Journal of Molecular Biology · 1992 · 114 citations

Biosynthesis, Cellular Enzymology, Biochemistry +4

Cloning, sequencing, overproduction and purification of trypanothione reductase from Trypanosoma cruzi

Frank Sullivan, Christopher A. Walsh · Molecular and Biochemical Parasitology · 1991 · 101 citations

Trypanosoma Cruzi, Biosynthesis, Biochemistry +9

Novel polyamine derivatives as potent competitive inhibitors of Trypanosoma cruzi trypanothione reductase

Mary C. O’Sullivan, Qibing Zhou · Bioorganic & Medicinal Chemistry Letters · 1995 · 26 citations

Potent Competitive Inhibitors, Biochemistry, Antiparasitic Agent +9