Novel APP K724M mutation causes Chinese early-onset familial Alzheimer's disease and increases amyloid-β42 to amyloid-β40 ratio

“Mini-mental state”

Marshal F. Folstein, Susan E. Folstein, Paul R. McHugh · Journal of Psychiatric Research · 1975 · 85.9K citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Alison Goate, Marie‐Christine Chartier‐Harlin, Jeremy Brown et al. · Nature · 1991 · 4.6K citations

Alzheimer's Disease, Genetics, Missense Mutation +9

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Donalyn Scheuner, Christopher B. Eckman, M. Jensen et al. · Nature Medicine · 1996 · 2.6K citations

Molecular Biology, Synaptic Signaling, Social Sciences +16

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

Thorlákur Jónsson, Jasvinder K. Atwal, Stacy Steinberg et al. · Nature · 2012 · 1.7K citations

Neurodegenerative Diseases, Alzheimer's Disease, Aging +10

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid

Fiona Crawford, Karin Axelman, Henry Houlden et al. · Nature Genetics · 1992 · 1.5K citations

Pathogenic Mutation, Neurodegenerative Diseases, Probable Alzheimer +12