Compared to mycophenolate mofetil, rapamycin induces significant changes on growth factors and growth factor receptors in the early days postkidney transplantation1

Abstract

Rapa was associated with a decreased synthesis of primarily monocyte-derived cytokines and enhanced production of TGF-beta(1), which in an appropriate cytokine milieu may promote allograft tolerance. The down-regulation of cytokine receptors and IL-2 may be associated with a depressed immune response towards the kidney allograft.