Concepedia

Evaluation of pyrrolidine and pyrazolone derivatives as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1)

Emanuele Amata, Nicholas D. Bland, R. Keith Campbell, Michael P. Pollastri

Tetrahedron Letters · 2015 · 58 citations · 11 references

DOI

Concepts

References

11

Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

Gérardo Priotto, S Kasparian, Wilfried Mutombo et al. · The Lancet · 2009 · 532 citations

, , +12

The <i>Trypanosoma brucei</i> cAMP phosphodiesterases TbrPDEBl and TbrPDEB2: flagellar enzymes that are essential for parasite virulence

Michael Oberholzer, Gabriela Marti, Mario Barešić et al. · The FASEB Journal · 2006 · 142 citations

, , +15

Target Repurposing for Neglected Diseases

Michael P. Pollastri, R. Keith Campbell · Future Medicinal Chemistry · 2011 · 97 citations

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Pharmacological Validation of Trypanosoma brucei Phosphodiesterases as Novel Drug Targets

Harry P. de Koning, Matthew K. Gould, Geert Jan Sterk et al. · The Journal of Infectious Diseases · 2012 · 94 citations · Full text

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Catechol Pyrazolinones as Trypanocidals: Fragment-Based Design, Synthesis, and Pharmacological Evaluation of Nanomolar Inhibitors of Trypanosomal Phosphodiesterase B1

Kristina M. Orrling, Chimed Jansen, Xuan Lan Vu et al. · Journal of Medicinal Chemistry · 2012 · 56 citations · Full text

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