Chimed Jansen

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Beatriz Baragaña, Barbara Forte, Ryan Choi et al. · Proceedings of the National Academy of Sciences · 2019 · 132 citations · Full text

Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM

Dhaval Varshney, Alain‐Pierre Petit, Juan A. Bueren‐Calabuig et al. · Nucleic Acids Research · 2016 · 80 citations · Full text

Protein Assembly, Molecular Regulation, Molecular Biology +18

PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design

Chimed Jansen, Albert J. Kooistra, Georgi K. Kanev et al. · Journal of Medicinal Chemistry · 2016 · 65 citations · Full text

Catechol Pyrazolinones as Trypanocidals: Fragment-Based Design, Synthesis, and Pharmacological Evaluation of Nanomolar Inhibitors of Trypanosomal Phosphodiesterase B1

Kristina M. Orrling, Chimed Jansen, Xuan Lan Vu et al. · Journal of Medicinal Chemistry · 2012 · 55 citations · Full text

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the <i>Plasmodium falciparum</i> Drug Target, Prolyl-tRNA-synthetase

Stephen N. Hewitt, David M. Dranow, Benjamin G. Horst et al. · ACS Infectious Diseases · 2016 · 54 citations · Full text

Structural Characterization, Drug Target, Bioorganic Chemistry +18