Concepedia

PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways

Xiaoxing Xiong, Rong Xie, Hongfei Zhang, Lijuan Gu, Weiying Xie, Michelle Cheng, Zhihong Jian, Kristina S. Kovacina, Heng Zhao

Neurobiology of Disease · 2014 · 87 citations · 41 references

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41

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

Emilie Vander Haar, Seong-il Lee, Sricharan Bandhakavi et al. · Nature Cell Biology · 2007 · 1.2K citations

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Trehalose, a Novel mTOR-independent Autophagy Enhancer, Accelerates the Clearance of Mutant Huntingtin and α-Synuclein

Sovan Sarkar, J. Eric Davies, Zebo Huang et al. · Journal of Biological Chemistry · 2006 · 1.1K citations · Full text

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PRAS40 Regulates mTORC1 Kinase Activity by Functioning as a Direct Inhibitor of Substrate Binding

Lifu Wang, Thurl E. Harris, Richard A. Roth et al. · Journal of Biological Chemistry · 2007 · 483 citations · Full text

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Identification of a Proline-rich Akt Substrate as a 14-3-3 Binding Partner

Kristina S. Kovacina, Grace Y. Park, Sun Sik Bae et al. · Journal of Biological Chemistry · 2003 · 364 citations · Full text

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Levels of mTOR and its downstream targets 4E‐BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain

Xu Li, Irina Alafuzoff, Hilkka Soininen et al. · FEBS Journal · 2005 · 325 citations

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