Eicosapentaenoic acid inhibits prostaglandin D₂ generation by inhibiting cyclo‐oxygenase‐2 in cultured human mast cells

Abstract

Pre-incubation with EPA primarily affects the COX-2 pathway in cultured human mast cells and reduces PGD2 generation in response to IgE-anti-IgE challenge incubation. These findings suggest that COX-1 and COX-2 have different substrate flow systems in mast cells. They also suggest that endogenous EPA diet supplementation would reduce PGD2 production and could serve as an anti-inflammatory substrate in human mast cells.