Impaired thymic expression of tissue-restricted antigens licenses the de novo generation of autoreactive CD4+ T cells in acute GVHD

Abstract

Key Points Loss of thymic ectopic self-antigen expression during murine acute GVHD is responsible for the de novo generation of autoreactive T cells. Functional impairment of the thymus medulla mechanistically links acute GVHD to posttransplantation autoimmunity.