Expression of Multidrug Resistance-Associated Protein (MRP) in Brain Microvessel Endothelial Cells

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994 · 2.3K citations

Medicine, Pharmacokinetics, Pharmacology +14

BindingDB Entry 50042057: Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump.

PubMed · 2013 · 576 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15

Tissue distribution of the multidrug resistance protein.

M J Flens, G J Zaman, Paul van der Valk et al. · PubMed · 1996 · 477 citations

Life Sciences, Pharmacokinetics, Pharmacology +10

Transport properties of the multidrug resistance‐associated protein (MRP) in human tumour cells

Zsolt Holló, László Homolya, Tamás Hegedűs et al. · FEBS Letters · 1996 · 198 citations

Medicine, Oncology, Pharmacology +17

Subcellular distribution of daunorubicin in P-glycoprotein-positive and -negative drug-resistant cell lines using laser-assisted confocal microscopy.

James E. Gervasoni, Scott Z. Fields, Sindu Krishna et al. · PubMed · 1991 · 158 citations

Medicine, Cancer Biology, Pharmacology +13