Concepedia

Potentiation of reactive oxygen species is a marker for synergistic cytotoxicity of MS-275 and 5-azacytidine in leukemic cells

Shan Gao, Aaron Mobley, Claudia P. Miller, Jessica Boklan, Joya Chandra

Leukemia Research · 2007 · 55 citations · 26 references

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References

26

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Ting‐Chao Chou, Paul Talalay · Advances in Enzyme Regulation · 1984 · 7.2K citations

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A synthetic inhibitor of histone deacetylase, MS-27-275, with marked <i>in vivo</i> antitumor activity against human tumors

Akiko Saito, Takashi Yamashita, Yukiyasu Mariko et al. · Proceedings of the National Academy of Sciences · 1999 · 696 citations · Full text

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Histone deacetylase (HDAC) inhibitor activation of p21 <sup>WAF1</sup> involves changes in promoter-associated proteins, including HDAC1

C. Gui, Lang Ngo, Weili Xu et al. · Proceedings of the National Academy of Sciences · 2004 · 554 citations · Full text

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Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors

Johanna Ungerstedt, Yoshihiro Sowa, Weili Xu et al. · Proceedings of the National Academy of Sciences · 2005 · 507 citations · Full text

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The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1.

Roberto R. Rosato, Jorge A. Almenara, Steven Grant · PubMed · 2003 · 470 citations

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