Jorge A. Almenara

The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1.

Roberto R. Rosato, Jorge A. Almenara, Steven Grant · PubMed · 2003 · 470 citations

Mixed-phenotype Acute Leukemia, Immunology, Cell Death +22

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia

Steven W. Paugh, Barbara S. Paugh, Mohamed Rahmani et al. · Blood · 2008 · 246 citations · Full text

Simultaneous activation of the intrinsic and extrinsic pathways by histone deacetylase (HDAC) inhibitors and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induces mitochondrial damage and apoptosis in human leukemia cells.

Roberto R. Rosato, Jorge A. Almenara, Yun Dai et al. · PubMed · 2003 · 230 citations

Mitophagy, Hdac Inhibitors, Chemoprevention Strategy +16

Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts

Dmitri Kapitonov, Jeremy C. Allegood, Clint Mitchell et al. · Cancer Research · 2009 · 179 citations · Full text

Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA)

Jorge A. Almenara, Roberto R. Rosato, Steven Grant · Leukemia · 2002 · 138 citations

Synergistic Induction, Mitophagy, Mitochondrial Damage +10