Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1Ra

Gout-associated uric acid crystals activate the NALP3 inflammasome

Fabio Martinon, Virginie Pétrilli, Annick Mayor et al. · Nature · 2006 · 5.1K citations · Full text

Inflammation, Nalp3 Inflammasome, Urology +7

Prevalence of gout and hyperuricemia in the US general population: The National Health and Nutrition Examination Survey 2007-2008

Yanyan Zhu, Bhavik J. Pandya, Hyon K. Choi · Arthritis & Rheumatism · 2011 · 1.8K citations · Full text

Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

Johanneke Kleinnijenhuis, Jessica Quintin, Frank Preijers et al. · Proceedings of the National Academy of Sciences · 2012 · 1.7K citations · Full text

Bcg Vaccination, Microbial Pathogens, Trained Immunity +30

Molecular identification of a danger signal that alerts the immune system to dying cells

Yan Shi, James Evans, Kenneth L. Rock · Nature · 2003 · 1.6K citations

Inflammation, Immune Evasion, Systems Biology +14

Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

Jessica Quintin, Sadia Saeed, Joost H.A. Martens et al. · Cell Host & Microbe · 2012 · 1.2K citations · Full text

Host Response, Pathogenesis, Immunology +7