Human Glyceraldehyde-3-phosphate Dehydrogenase Plays a Direct Role in Reactivating Oxidized Forms of the DNA Repair Enzyme APE1

S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding

Makoto R. Hara, Nishant Agrawal, Sangwon F. Kim et al. · Nature Cell Biology · 2005 · 1.1K citations

Signal Transduction, Cell Regulation, Natural Sciences +12

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

Steven Xanthoudakis, Graham G. Miao, F. Wang et al. · The EMBO Journal · 1992 · 922 citations · Full text

Reductive Stress, Redox Signaling, Genome Instability +10

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

Kiichi Hirota, Minoru Matsui, Satoshi Iwata et al. · Proceedings of the National Academy of Sciences · 1997 · 833 citations · Full text

Molecular Regulation, Redox Regulation, Genetics +22

Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.

Steven Xanthoudakis, Tom Curran · The EMBO Journal · 1992 · 713 citations · Full text

Chromatin, Transcriptional Regulation, Chromatin Remodeling +10

Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes.

Bruce Demple, Tim Herman, Ding‐Shinn Chen · Proceedings of the National Academy of Sciences · 1991 · 534 citations · Full text

Genome Instability, Natural Sciences, Genetics +13