Different effects of inhibitors on the O  - and N  -demethylation of codeine in human liver microsomes

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

F. Peter Guengerich, M V Martin, Philippe Beaune et al. · Journal of Biological Chemistry · 1986 · 730 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs

Thomas Kronbach, Volker Fischer, Urs Meyer · Clinical Pharmacology & Therapeutics · 1988 · 539 citations

Medicine, Biochemistry, Pharmacology +17

Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.

Lydiane Pichard, Isabelle Fabre, Gérard Fabre et al. · Drug Metabolism and Disposition · 1990 · 437 citations

Medicine, Pharmacology, Toxicology +17

Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

Inger Johansson, Mikael Oscarson, Qun‐Ying Yue et al. · Molecular Pharmacology · 1994 · 430 citations

Medicine, Genetics, Molecular Genetics +16

A potentially hazardous interaction between erythromycin and midazolam

Klaus T. Olkkola, Kari Aranko, Harri Luurila et al. · Clinical Pharmacology & Therapeutics · 1993 · 354 citations

Medicine, Pharmacokinetics, Pharmacology +13