Concepedia

A new method for measuring the free fraction of cyclosporin in plasma by equilibrium dialysis

S Henricsson

Journal of Pharmacy and Pharmacology · 1987 · 25 citations · 5 references

DOI

Concepts

Abstract

The free fraction of cyclosporin in plasma has been measured by equilibrium dialysis in steel chambers. Equilibration time was 16 h. The intra-assay coefficient of variation was 7%. The free fraction remained constant in plasma samples frozen for up to 6 months, and was independent of the total concentration within the therapeutic range.

References

5

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Michel Lemaire, J.P. Tillement · Journal of Pharmacy and Pharmacology · 1982 · 271 citations

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Drug Treatment. Principles and Practice of Clinical Pharmacology and Therapeutics.

Annals of Internal Medicine · 1980 · 226 citations · Full text

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Binding of amobarbital, pentobarbital and diphenylhydantoin to blood cells and plasma proteins in healthy volunteers and uraemic patients

M. Ehrnebo, I. Odar-Cederl�f · European Journal of Clinical Pharmacology · 1975 · 66 citations

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Influence of volume shifts on drug binding during equilibrium dialysis: Correction and attenuation

John J. Lima, Janis J. MacKichan, Nicholas Libertin et al. · Journal of Pharmacokinetics and Biopharmaceutics · 1983 · 56 citations

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The pharmacokinetics of cyclosporine. II. Blood plasma distribution and binding studies.

Walid M. Awni, Ronald J. Sawchuk · Drug Metabolism and Disposition · 1985 · 24 citations

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