Replicative Senescence in Human Uroepithelial Cells

The serial cultivation of human diploid cell strains

Leonard Hayflick, Paul S. Moorhead · Experimental Cell Research · 1961 · 8.3K citations

Human Cell, Cell Division, Genetics +5

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell · 1997 · 5K citations · Full text

Developmental Biology, Oncogenic Agent, Cellular Senescence +6

Telomere length predicts replicative capacity of human fibroblasts.

Richard Allsopp, Homayoun Vaziri, Cam Patterson et al. · Proceedings of the National Academy of Sciences · 1992 · 2.2K citations · Full text

Genome Instability, Fibrosis, Xenotransplantation +13

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

Takehiko Kamijo, Frédérique Zindy, Martine F. Roussel et al. · Cell · 1997 · 1.6K citations · Full text

Knockout Mouse, Medicine, Tumor Suppression +9

Cold Spring Harbor Symposia on Quantitative Biology.

H. Berg · Journal of Electroanalytical Chemistry · 1989 · 1.2K citations

Biology, Integrative Biology