The effects of the SLCO2B1 c.1457C>T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans - Concepedia

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The effects of the SLCO2B1 c.1457C>T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans

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References

2010

Year

Junko Imanaga, Tsutomu Kotegawa, Hiromitsu Imai, Kimiko Tsutsumi, Tsuneaki Yoshizato, Tetsuji Ohyama, Yoshiyuki Shirasaka, Ikumi Tamai, Tomonori Tateishi, Kyoichi Ohashi

Pharmacogenetics and Genomics

Abstract

The results suggest that fexofenadine is a substrate of OATP2B1, and the transport function of OATP2B1 is subject to the genotype of SLCO2B1 c.1457C> T and apple juice. It is likely that apple juice has little effect on CYP3A.