Concepedia

Effect of Oral Ketoconazole on Oral and Intravenous Pharmacokinetics of Simvastatin and Its Acid in Cynomolgus Monkeys

Akihito Ogasawara, Masahiro Utoh, Kazuo Nii, Ayumi Ueda, Takahiro Yoshikawa, Toshiyuki Kume, Koichiro Fukuzaki

Drug Metabolism and Disposition · 2008 · 19 citations · 24 references

DOI

Concepts

References

24

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism*

Kenneth E. Thummel, Diarmuid O’Shea, Mary F. Paine et al. · Clinical Pharmacology & Therapeutics · 1996 · 619 citations

, , +17

The Utility of in Vitro Cytochrome P450 Inhibition Data in the Prediction of Drug-Drug Interactions

R. Scott Obach, Robert L. Walsky, Karthik Venkatakrishnan et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 437 citations

, , +17

Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole*

Pertti J. Neuvonen, Teemu Kantola, Kari T. Kivistö · Clinical Pharmacology & Therapeutics · 1998 · 403 citations

, , +11

Grapefruit juice—simvastatin interaction: Effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors*

Jari J. Lilja, Kari T. Kivistö, Pertti J. Neuvonen · Clinical Pharmacology & Therapeutics · 1998 · 310 citations

, , +13

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine*

Denise Y. Gomez, Vincent J. Wacher, Stephen J. Tomlanovich et al. · Clinical Pharmacology & Therapeutics · 1995 · 282 citations

, , +14