Concepedia

Validation of a pH gradient-based ion-exchange chromatography method for high-resolution monoclonal antibody charge variant separations

Jennifer C. Rea, G. Tony Moreno, Yun Lou, Dell Farnan

Journal of Pharmaceutical and Biomedical Analysis · 2010 · 78 citations · 15 references

DOI

Concepts

References

15

The United States Pharmacopeial Convention

New England Journal of Medicine · 1910 · 916 citations

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Monoclonal antibody successes in the clinic

Janice M. Reichert, Clark Rosensweig, Laura Faden et al. · Nature Biotechnology · 2005 · 727 citations

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A study in glycation of a therapeutic recombinant humanized monoclonal antibody: Where it is, how it got there, and how it affects charge-based behavior

Cynthia Quan, Emily W. Alcala, Irena Petkovska et al. · Analytical Biochemistry · 2007 · 201 citations

, , +16

Characterization of Noncovalent Complexes of Recombinant Human Monoclonal Antibody and Antigen Using Cation Exchange, Size Exclusion Chromatography, and BIAcore

Ling C. Santora, Zehra Kaymakcalan, Paul Sakorafas et al. · Analytical Biochemistry · 2001 · 107 citations

, , +17

Multiproduct High-Resolution Monoclonal Antibody Charge Variant Separations by pH Gradient Ion-Exchange Chromatography

Dell Farnan, G. Tony Moreno · Analytical Chemistry · 2009 · 104 citations

, , +15