PDE5A suppression of acute β-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation

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Cardiac Muscle, Cardiomyopathy, Molecular Physiology +9

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The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle.

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Heart Failure, Nitric Oxide, Pharmacotherapy +16

8-bromo-cGMP reduces the myofilament response to Ca2+ in intact cardiac myocytes.

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Phosphodiesterase-5 Inhibition With Sildenafil Attenuates Cardiomyocyte Apoptosis and Left Ventricular Dysfunction in a Chronic Model of Doxorubicin Cardiotoxicity

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