Publication | Open Access
PDE5A suppression of acute β-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation
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2010
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Molecular PharmacologySignal TransductionMolecular PhysiologySignaling PathwayMedicinePkg-mediated TroponinPhysiologyReceptor (Biochemistry)Pde5a SuppressionAcute β-Adrenergic ActivationCellular BiochemistryPharmacologyCell SignalingCellular PhysiologyProtein Phosphorylation
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The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle. Charles Gauthier, Véronique Leblais, Lester Kobzik, Journal of Clinical Investigation Heart FailureNitric OxidePharmacotherapySocial SciencesCardiac Contraction | 1998 | 383 |
1994 | 375 | |
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