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Delayed onset of hyperglycaemia in a mouse model with impaired glucagon secretion demonstrates that dysregulated glucagon secretion promotes hyperglycaemia and type 2 diabetes

Natalia Gustavsson, T. Seah, Ye Lao, G. K. Radda, Thomas C. Südhof, Weiping Han

Diabetologia · 2010 · 12 citations · 13 references

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References

13

THE ESSENTIAL ROLE OF GLUCAGON IN THE PATHOGENESIS OF DIABETES MELLITUS

RogerH Unger, Lelio Orci · The Lancet · 1975 · 595 citations

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Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels

Patrik Rorsman, Per‐Olof Berggren, Krister Bokvist et al. · Nature · 1989 · 461 citations

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Islet β-cell secretion determines glucagon release from neighbouring α-cells

Hisamitsu Ishihara, Pierre Maechler, Asllan Gjinovci et al. · Nature Cell Biology · 2003 · 384 citations

, , +14

β-Cell Secretory Products Activate α-Cell ATP-Dependent Potassium Channels to Inhibit Glucagon Release

Isobel Franklin, Jesper Gromada, Asllan Gjinovci et al. · Diabetes · 2005 · 298 citations

, , +17

Insulin within islets is a physiologic glucagon release inhibitor.

Hiroshi Maruyama, Akitaka Hisatomi, Lelio Orci et al. · Journal of Clinical Investigation · 1984 · 296 citations · Full text

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