Is a Nitrogen Atom an Important Pharmacophoric Element in Sigma Ligand Binding?

Steroid Binding at σ Receptors Suggests a Link Between Endocrine, Nervous, and Immune Systems

Tsung‐Ping Su, Edythe D. London, Jerome H. Jaffe · Science · 1988 · 542 citations

Life Sciences, Endocrinology, Immunology +17

Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors

Richard Bergeron, Claude de Montigny, Guy Debonnel · Journal of Neuroscience · 1996 · 299 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Intracellular σ ₁ receptor modulates phospholipase C and protein kinase C activities in the brainstem

M.P. Morin‐Surun, Thibault Collin, Monique Denavit‐Saubié et al. · Proceedings of the National Academy of Sciences · 1999 · 168 citations · Full text

Life Sciences, Neurobiology, Neuroscience +14

Structural Features Important for .sigma.1 Receptor Binding

Richard A. Glennon, Seth Y. Ablordeppey, Abd M. Ismaiel et al. · Journal of Medicinal Chemistry · 1994 · 138 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Two novel σ receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity

Kari A. McCracken, Wayne D. Bowen, Brian R. de Costa et al. · European Journal of Pharmacology · 1999 · 113 citations

Medicine, Neuroscience, Pharmacology +16