Concepedia

Genetic Variants in Toll-Like Receptors Are Not Associated with Rheumatoid Arthritis Susceptibility or Anti-Tumour Necrosis Factor Treatment Outcome

Marieke J. H. Coenen, Christian Enevold, Pilar Barrera, Mascha M.V.A.P. Schijvenaars, Erik J. M. Toonen, Hans Scheffer, Leonid Padyukov, Alf Kastbom, Lars Klareskog, Anne Barton,

PLoS ONE · 2010 · 30 citations · 24 references

DOIFull text

Open access

Abstract

We conclude that genetic variants in TLRs do not play a major role in susceptibility for developing RA nor in anti-TNF treatment outcome in a Caucasian population.

References

24

PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses

Shaun Purcell, Benjamin M. Neale, Katherine EO Todd-Brown et al. · The American Journal of Human Genetics · 2007 · 34.9K citations · Full text

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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Paul R. Burton, David Clayton, Lon R. Cardon et al. · Nature · 2007 · 9.6K citations · Full text

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Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

Lucia A. Hindorff, Praveen Sethupathy, Heather Junkins et al. · Proceedings of the National Academy of Sciences · 2009 · 4.1K citations

<i>TRAF1–C5</i> as a Risk Locus for Rheumatoid Arthritis — A Genomewide Study

Robert M. Plenge, Mark Seielstad, Leonid Padyukov et al. · New England Journal of Medicine · 2007 · 828 citations · Full text

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk

Soumya Raychaudhuri, Brian Thomson, Elaine F. Remmers et al. · Nature Genetics · 2009 · 350 citations

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