Journal of Neurochemistry · 1979 · 75 citations · 19 references
Life SciencesBiochemistryNeuroscienceCytoskeletonEnzyme MechanismEnzymologyCalcium SignalingCytoskeletal Associated ProteinsIntracellular Calcium SignalingProtein DegradationProteolytic EnzymesProteolytic ProcessingCalcium-dependent Enzyme ActivationCalpain ActivityCalpain SystemCalpain-mediated ProteolysisCytoskeletal Severing EnzymesExtracellular ProteasesNeurofilament ProteinsProteolytic Pathways
Abstract Evidence for a protease in squid axoplasm which is selectively activated by Ca 2+ and blocked by SH‐inhibitors is presented. This protease appears to be particularly effective in degrading squid neurofilament proteins, but also extensively degrades various other major protein components in axoplasm.
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