Concepedia

γ-Radiation Promotes Immunological Recognition of Cancer Cells through Increased Expression of Cancer-Testis Antigens In Vitro and In Vivo

Anu Sharma, Beata Bode, Roland H. Wenger, Kuno Lehmann, Alessandro A. Sartori, Holger Moch, Alexander Knuth, Lotta von Boehmer, Maries van den Broek

PLoS ONE · 2011 · 130 citations · 28 references

DOIFull text

Open access

Abstract

Our findings suggest that γ-radiation promotes the immunological recognition of the tumor. We therefore propose that combining radiotherapy with treatments that support tumor specific immunity may result in increased therapeutic efficacy.

References

28

Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

Jérôme Galon, Anne Costes, Fátima Sánchez‐Cabo et al. · Science · 2006 · 6.3K citations

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A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

Pierre van der Bruggen, Catia Traversari, Patrick Chomez et al. · Science · 1991 · 3.5K citations

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Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

Eric A. Reits, James W. Hodge, Carla Herberts et al. · The Journal of Experimental Medicine · 2006 · 1.7K citations · Full text

Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment

Youjin Lee, Sogyong Auh, Yugang Wang et al. · Blood · 2009 · 1.3K citations · Full text

Local Radiation Therapy of B16 Melanoma Tumors Increases the Generation of Tumor Antigen-Specific Effector Cells That Traffic to the Tumor

Amit A. Lugade, James P. Moran, Scott A. Gerber et al. · The Journal of Immunology · 2005 · 930 citations · Full text