Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Warren J. Strittmatter, Ann M. Saunders, D. E. Schmechel et al. · Proceedings of the National Academy of Sciences · 1993 · 4.3K citations · Full text

Life Sciences, Genetics, Neurology +17

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

Mary P. Lambert, Avlin Barlow, Brett A. Chromy et al. · Proceedings of the National Academy of Sciences · 1998 · 3.5K citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

Yoshio Namba, Masanori Tomonaga, Hiroshi Kawasaki et al. · Brain Research · 1991 · 1.2K citations

Life Sciences, Neurology, Neuroscience +16

Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions

G. William Rebeck, Joell S. Reiter, Dudley K. Strickland et al. · Neuron · 1993 · 1.1K citations

Life Sciences, Genetics, Molecular Genetics +17

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

David M. Holtzman, Kelly R. Bales, Tanya Tenkova et al. · Proceedings of the National Academy of Sciences · 2000 · 943 citations

Life Sciences, Neurology, Neuroscience +17