Wortmannin, a Widely Used Phosphoinositide 3-Kinase Inhibitor, also Potently Inhibits Mammalian Polo-like Kinase

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

Edward H. Walker, Michael E. Pacold, Olga Perišić et al. · Molecular Cell · 2000 · 1.2K citations · Full text

Life Sciences, Biochemistry, Pharmacology +14

Activity-based protein profiling: The serine hydrolases

Yongsheng Liu, Matthew P. Patricelli, Benjamin F. Cravatt · Proceedings of the National Academy of Sciences · 1999 · 1.1K citations

Life Sciences, Biochemistry, Molecular Biology +16

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3‐kinase inhibitors, wortmannin and LY294002.

G.J. Brunn, Josie M. Williams, Candace J. Sabers et al. · The EMBO Journal · 1996 · 723 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +14

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.

Heidi A. Lane, Erich A. Nigg · The Journal of Cell Biology · 1996 · 690 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

Matthias P. Wymann, Ginette Bulgarelli-Leva, Marketa Zvelebil et al. · Molecular and Cellular Biology · 1996 · 680 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16