Concepedia

Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes

Aaron B. Bowman, Yung C. Lam, Paymaan Jafar‐Nejad, Hung-Kai Chen, Ronald Richman, Rodney C. Samaco, John Denis Fryer, Juliette J. Kahle, Harry T. Orr, Huda Y. Zoghbi

Nature Genetics · 2007 · 87 citations · 28 references

DOI

Concepts

References

28

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

Montserrat Arrasate, Siddhartha Mitra, Erik S. Schweitzer et al. · Nature · 2004 · 2K citations

, , +15

Huntingtin Controls Neurotrophic Support and Survival of Neurons by Enhancing BDNF Vesicular Transport along Microtubules

Laurent Gauthier, Bénédicte C. Charrin, María Borrell-Pagés et al. · Cell · 2004 · 1.1K citations · Full text

, , +14

Transcriptional Repression of PGC-1α by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration

Libin Cui, Hyunkyung Jeong, Fran Borovečki et al. · Cell · 2006 · 990 citations · Full text

, , +16

Ataxin-1 Nuclear Localization and Aggregation

Ivan A. Klement, Pamela J. Skinner, Michael D. Kaytor et al. · Cell · 1998 · 962 citations · Full text

, , +8

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

Chiara Zuccato, Marzia Tartari, Andrea Crotti et al. · Nature Genetics · 2003 · 934 citations

, , +9